Biomarkers in Breast Cancer (Cancer Drug Discovery and Development) by Giampietro Gasparini and Daniel F. Hayes covers both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Book Details
Book Details
- Hardcover: 360 pages
- Publisher: Humana Press; 1 edition (October 1, 2005)
- Language: English
- ISBN-10: 1588292274
- ISBN-13: 9781588292278
- Product Dimensions: 9.1 x 6 x 1.2 inches
- List Price: $165.00
