Cancer Drug Resistance (Cancer Drug Discovery and Development) by Beverly A. Teicher review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Book Details
Book Details
- Hardcover: 640 pages
- Publisher: Humana Press; 1 edition (March 9, 2006)
- Language: English
- ISBN-10: 1588295303
- ISBN-13: 9781588295309
- Product Dimensions: 10.2 x 7.2 x 0.9 inches
- List Price: $185.00
