Part I Molecules and Pathways of Apoptosis
The first edition of Essentials of Apoptosis: A Guide for Basic and Clinical Research by Xiao-Ming Yin was published in 2003. It was intended to provide the basic and essential information of apoptosis for those who were new to the field and who wanted to apply the knowledge to their own research. The book therefore focused on the concepts, the basic molecular architecture, and the pathophysiological significance of apoptosis. Since the first edition, there have been tremendous new developments in the field of apoptosis and cell death in general. The concept of various types of cell death has been further developed. The studies in both basic and clinical disciplines have been greatly expanded. In particular, notable progress has been made in extending the work into the therapeutic arena. As a result, the field has matured considerably and developed extensive cross-talk with works in other fields.
The author strive to incorporate and reflect these new developments in the second edition of this book. This book provide readers with the most updated and advanced knowledge in the field, while maintaining the fundamental information as presented in the first edition. To this end, the book has been significant expanded, not only in the page and chapter numbers but more importantly in the depth of coverage. Most of the chapters have been revised and/or rewritten, and 15 new chapters have been added to give rise to a total of 31 chapters.
- 1 Caspases: Activation, Regulation, and Function
- 2 The Bcl-2 Family Proteins
- 3 The Mammalian IAPs: Multifaceted Inhibitors of Apoptosis
- 4 Structural Biology of Programmed Cell Death
- 5 The Death Receptor Pathway
- 6 The Mitochondrial Pathway: Focus on Shape Changes
- 7 The Endoplasmic Reticulum Pathway
- 8 Reactive Oxygen Species in Cell Fate Decisions
- 9 The Integration of Metabolism and Cell Death
- 10 Transcriptional Regulation of Apoptosis
- 11 Clearance of Apoptotic Cells – Mechanisms and Consequences
- 12 Systems Biology Approaches to the Study of Apoptosis
- 13 Programmed Cell Death in Plants: Apoptotic but Not Quite
- 14 Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae
- 15 Programmed Cell Death in C. elegans
- 16 Cell Death in Drosophila
- 17 Cell Death: Defining and Misshaping Mammalian Embryos
- 18 Matters of Life and Death in the Immune System
- 19 Cell Death in the Hematopoietic System
- 20 Cell Death in Acute Neuronal Injury
- 21 Apoptosis in Neurodegenerative Diseases
- 22 Apoptosis in Cardiovascular Pathogenesis
- 23 Apoptosis in Lung Injury and Disease
- 24 Apoptosis in Liver Injury and Liver Diseases
- 25 Apoptosis in Acute Kidney Injury
- 26 Apoptosis in Cancer Biology and Cancer Therapeutics
- 27 Necrosis: Molecular Mechanisms and Physiological Roles
- 28 Caspase-Independent Mitotic Death
- 29 Lysosomal Proteases in Cell Death
- 30 Autophagy and Cell Death
- 31 Analysis of Apoptosis: Basic Principles and Protocols
The author strive to incorporate and reflect these new developments in the second edition of this book. This book provide readers with the most updated and advanced knowledge in the field, while maintaining the fundamental information as presented in the first edition. To this end, the book has been significant expanded, not only in the page and chapter numbers but more importantly in the depth of coverage. Most of the chapters have been revised and/or rewritten, and 15 new chapters have been added to give rise to a total of 31 chapters.
- In Part I, in addition to the discussion of the major apoptosis molecules, the activation and regulatory pathways, and the clearance of apoptotic cells, also present important issues that examine apoptosis from more integrated points of view. Thus, the roles of reactive oxygen species, metabolism, and transcription control in apoptosis activation and regulation are explored. A new systems biology approach to studying apoptosis is also introduced.
- In Part II, discuss apoptosis and cell death in four model systems, including plant, yeast, C. elegans, and Drosophila, which together have contributed greatly to our current understanding of cell death.
- In Part III, we focus on mammalian cell death under various pathophysiological situations in all major systems, including the hematopoietic and immune system, the brain, the heart, the liver, the lung, and the kidney. Two integrated chapters discussing cell death in normal development and in cancer biology have also been included.
- Furthermore, a separate Part IV has been added to discuss the alternative mechanisms and pathways of cell death.
- Finally, Part V discusses the technical aspect of apoptosis research.
Book Details
- Hardcover: 707 pages
- Publisher: Humana Press; 2nd edition (June 4, 2009)
- Language: English
- ISBN-10: 1603273808
- ISBN-13: 978-1603273800
- Product Dimensions: 9.3 x 6.2 x 1.7 inches
- List Price: $149.00