The European Society for Medical Oncology (ESMO) is to be complimented for having decided to dedicate an issue of its “Handbook” series to geriatric oncology. The International Society for Geriatric Oncology (SIOG) has been happy to help in the task of developing this volume, which was initiated by Dirk Schrijvers, Branko Zakotnik, Riccardo Audisio, Hendrik van Halteren, Arti Hurria, and the undersigned. This handbook is not only for Europeans. Cancer is a disease related to ageing, and the proportion of senior patients increases worldwide. While the proportion of persons beyond age 70 is still small in developing countries, their numerous population means that there are more “elderlies” in India than in Europe.
The authors have done a major effort in providing in record time chapters that truly reflect the state of the art in the management of senior adults with cancer. Many questions in this advancing field need considerable work before adequate guidelines can be provided. Nevertheless, progress is being made and is reflected by the contributions.
Some diseases have not been discussed and interesting topics have not been addressed. This gap is filled by more comprehensive books, and today’s electronic communications allow one to explore any area of interest easily.
The treatment of any patient requires a careful evaluation of the person who is in need of such treatment. This is even truer for the seniors, who have less reserves to cope with cancer and its treatment. Therefore, this handbook leaves ample space for chapters that help in the delicate decisionmaking process, which should lead to the best therapy, adapted not only to the disease but also to the person who suffers from it. Annals of Oncology, the official journal of ESMO, and the soon-to-belaunched Journal of Geriatric Oncology, official journal of SIOG, will keep us updated, as will all major medical journals.
Contents
Chapter 1 Introduction
Defining the Elderly
Biology of Aging and Changes in Organ Function
Changes in Cognition
Cancer and Aging
Clinical Aspects
Chapter 2 Cancer Epidemiology
Introduction
Population Demographics
Cancer Demographics
Society-Related Problems
Chapter 3 Evaluation of the Senior Cancer Patient: Comprehensive Geriatric Assessment and Screening Tools for the Elderly
Introduction
Short Screening Tools
The Vulnerable Elders Survey
MGA Packages
Chapter 4 Frailty in the Elderly
Frailty in the Elderly
The Impact of Frailty on Cancer
Assessment of Frailty
Conclusion
Further Reading
Chapter 5 Surgical Treatment
Introduction
Indications for Surgery
Patients Selection
Outcomes
Survival
Palliation
Side Effects
Chapter 6 Radiotherapy in the Elderly Cancer Patient
Indications for Radiotherapy in the Elderly
Side Effects of Radiotherapy in the Elderly (Acute and Late)
Efficacy and Outcome of Radiotherapy in the Aging
Palliative Setting: Toxicity and Efficacy Ratio
Curative Setting: Combinations of Chemotherapy and Radiotherapy
Selection Criteria for Radiotherapy in the Elderly
Chapter 7 Hormonal Anticancer Treatment in the Senior Cancer Patient
Introduction
Breast Cancer
Prostate Cancer
Chapter 8 Cytotoxic and Targeted Anticancer Treatment in the Senior Cancer Patient
Introduction
Chemotherapy in Senior Adults
Targeted Therapies in Senior Adults
Further Reading
Chapter 9 Treatment of Lymphoma in the Elderly Population
Introduction
Diagnosis and Prognosis
Treatment
Chapter 10 Management of Myeloproliferative Diseases in Senior Patients
Diagnosis and Classification of Myeloproliferative Disorders
Treatment Strategies of MPD in the Senior Patient
Chapter 11 Myelodysplastic Syndromes in the Senior Patient
The Relevance of Myelodysplastic Syndromes in the Elderly
Classification and Risk Scoring in MDS
Age-Adjusted Models and Assessment in Elderly MDS Patients
Treatment Options in Elderly MDS Patients
Future Perspectives
Chapter 12 Breast Cancer in the Senior Patient
Introduction
Early Breast Cancer
Metastatic Breast Cancer
Chapter 13 Lung Cancer in the Elderly
Introduction
Early Non–Small Cell Lung Cancer in the Elderly
Advanced Non–Small Cell Lung Cancer in the Elderly
Small Cell Lung Cancer in the Elderly
Palliative Treatment in Elderly Lung Cancer Patients
Chapter 14 Colorectal Cancer
Introduction
Adjuvant Chemotherapy
Metastatic Disease
Chapter 15 Prostate Cancer
Introduction and General Background
Treatment of Localized Prostate Cancer in Senior Adult Patients
Treatment of Metastatic Prostate Cancer in Senior Adult Patients
Chapter 16 Bladder Cancer
Incidence and Mortality
Etiology and Risk Factors
Pathology
Natural History and Tumor Biology
Signs and Symptoms
Imaging, Cystoscopy, and Urinary Cytopathology
Staging
Treatment of NMIBC
Surgical Treatment
Radiotherapy
Organ-Sparing Treatments
Systemic Chemotherapy
Prognosis of BC
Follow-Up
Chapter 17 Gynecological Cancer in the Senior Patient
Introduction
Cervical Cancer
Uterine Cancer
Special Types of Endometrial Malignancy
Vaginal Cancer
Vulvar Cancer
Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer
Chapter 18 Head and Neck Cancer in the Elderly
Introduction
Surgery
Radiotherapy
Chemotherapy
Targeted Therapies
Chapter 19 Renal Cell Cancer
Introduction
Surgery in the Senior Cancer Patient
Systemic Therapy of Metastatic Renal Cell Carcinoma in the Senior Cancer Patient
Patient-Focused Approach
Conclusion
Further Reading
Chapter 20 Psychological Problems in Older Cancer Patients
Introduction
Depression
Anxiety
Chapter 21 Social and Ethical Aspects
Introduction
Respect
Admiration
Attention
Information
Protection
Diagnosis
Care
Time
Caution
Freedom
Further Reading
Chapter 22 The Role of the Multidisciplinary Team
Introduction
The Assessment of Age
Polypharmacy
Management of the Caregiver
Function of the Team
Index
The authors have done a major effort in providing in record time chapters that truly reflect the state of the art in the management of senior adults with cancer. Many questions in this advancing field need considerable work before adequate guidelines can be provided. Nevertheless, progress is being made and is reflected by the contributions.
Some diseases have not been discussed and interesting topics have not been addressed. This gap is filled by more comprehensive books, and today’s electronic communications allow one to explore any area of interest easily.
The treatment of any patient requires a careful evaluation of the person who is in need of such treatment. This is even truer for the seniors, who have less reserves to cope with cancer and its treatment. Therefore, this handbook leaves ample space for chapters that help in the delicate decisionmaking process, which should lead to the best therapy, adapted not only to the disease but also to the person who suffers from it. Annals of Oncology, the official journal of ESMO, and the soon-to-belaunched Journal of Geriatric Oncology, official journal of SIOG, will keep us updated, as will all major medical journals.
Contents
Chapter 1 Introduction
Defining the Elderly
Biology of Aging and Changes in Organ Function
Changes in Cognition
Cancer and Aging
Clinical Aspects
Chapter 2 Cancer Epidemiology
Introduction
Population Demographics
Cancer Demographics
Society-Related Problems
Chapter 3 Evaluation of the Senior Cancer Patient: Comprehensive Geriatric Assessment and Screening Tools for the Elderly
Introduction
Short Screening Tools
The Vulnerable Elders Survey
MGA Packages
Chapter 4 Frailty in the Elderly
Frailty in the Elderly
The Impact of Frailty on Cancer
Assessment of Frailty
Conclusion
Further Reading
Chapter 5 Surgical Treatment
Introduction
Indications for Surgery
Patients Selection
Outcomes
Survival
Palliation
Side Effects
Chapter 6 Radiotherapy in the Elderly Cancer Patient
Indications for Radiotherapy in the Elderly
Side Effects of Radiotherapy in the Elderly (Acute and Late)
Efficacy and Outcome of Radiotherapy in the Aging
Palliative Setting: Toxicity and Efficacy Ratio
Curative Setting: Combinations of Chemotherapy and Radiotherapy
Selection Criteria for Radiotherapy in the Elderly
Chapter 7 Hormonal Anticancer Treatment in the Senior Cancer Patient
Introduction
Breast Cancer
Prostate Cancer
Chapter 8 Cytotoxic and Targeted Anticancer Treatment in the Senior Cancer Patient
Introduction
Chemotherapy in Senior Adults
Targeted Therapies in Senior Adults
Further Reading
Chapter 9 Treatment of Lymphoma in the Elderly Population
Introduction
Diagnosis and Prognosis
Treatment
Chapter 10 Management of Myeloproliferative Diseases in Senior Patients
Diagnosis and Classification of Myeloproliferative Disorders
Treatment Strategies of MPD in the Senior Patient
Chapter 11 Myelodysplastic Syndromes in the Senior Patient
The Relevance of Myelodysplastic Syndromes in the Elderly
Classification and Risk Scoring in MDS
Age-Adjusted Models and Assessment in Elderly MDS Patients
Treatment Options in Elderly MDS Patients
Future Perspectives
Chapter 12 Breast Cancer in the Senior Patient
Introduction
Early Breast Cancer
Metastatic Breast Cancer
Chapter 13 Lung Cancer in the Elderly
Introduction
Early Non–Small Cell Lung Cancer in the Elderly
Advanced Non–Small Cell Lung Cancer in the Elderly
Small Cell Lung Cancer in the Elderly
Palliative Treatment in Elderly Lung Cancer Patients
Chapter 14 Colorectal Cancer
Introduction
Adjuvant Chemotherapy
Metastatic Disease
Chapter 15 Prostate Cancer
Introduction and General Background
Treatment of Localized Prostate Cancer in Senior Adult Patients
Treatment of Metastatic Prostate Cancer in Senior Adult Patients
Chapter 16 Bladder Cancer
Incidence and Mortality
Etiology and Risk Factors
Pathology
Natural History and Tumor Biology
Signs and Symptoms
Imaging, Cystoscopy, and Urinary Cytopathology
Staging
Treatment of NMIBC
Surgical Treatment
Radiotherapy
Organ-Sparing Treatments
Systemic Chemotherapy
Prognosis of BC
Follow-Up
Chapter 17 Gynecological Cancer in the Senior Patient
Introduction
Cervical Cancer
Uterine Cancer
Special Types of Endometrial Malignancy
Vaginal Cancer
Vulvar Cancer
Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer
Chapter 18 Head and Neck Cancer in the Elderly
Introduction
Surgery
Radiotherapy
Chemotherapy
Targeted Therapies
Chapter 19 Renal Cell Cancer
Introduction
Surgery in the Senior Cancer Patient
Systemic Therapy of Metastatic Renal Cell Carcinoma in the Senior Cancer Patient
Patient-Focused Approach
Conclusion
Further Reading
Chapter 20 Psychological Problems in Older Cancer Patients
Introduction
Depression
Anxiety
Chapter 21 Social and Ethical Aspects
Introduction
Respect
Admiration
Attention
Information
Protection
Diagnosis
Care
Time
Caution
Freedom
Further Reading
Chapter 22 The Role of the Multidisciplinary Team
Introduction
The Assessment of Age
Polypharmacy
Management of the Caregiver
Function of the Team
Index
Product Details
- Authors: Dirk Schrijvers, Matti Aapro, Branko Zakotnik and Riccardo Audisio
- Paperback: 168 pages
- Publisher: Informa Healthcare; 1 edition (May 15, 2010)
- Language: English
- ISBN-10: 1841847097
- ISBN-13: 978-1841847092
- Product Dimensions: 7.2 x 4.8 x 0.5 inches