Oral Cancer is a neoplasm with a fairly large male to female ration in most populations. Moreover, it develops in older age in females in comparison with males, and the ration of non-smokers, non-drinkers among elderly female oral cnacer cases if suprisingly high. The conspicuously lower incidence of this tumor among women than men is suggestive of certain endocrine involvement in its development. There are no available literary data as yet which would give an explantion to this gender specific incidence of oral cancer. Oral cancer is a multicasual disease and there are thorough interrelationships among the etiologic factors. Till now, exogenous harmful noxae (tobacco, alcohol comsumption and energy rich diet) were overemphasized in its epidemology. However, these exogenous factors have not only local carcinogenic effect in the oral cavity, but also induce systemtic changes by means of metabolic and hormonal pathways. With full knowledge of these correlations, isolated investigations of exogenous risk factors may be misleading.
Nowadays, all anticancer agents have severe, toxic effects, killing the hemopoetic cells and thoroughly suppressing the immune system of the patient. One of our old dreams may come true with recognition of the anticancer capacity of estrogen. This new panacea is ideal for cancer cure as it has regulatory effects on cell proliferation and opposes growth factor activities. Moreover, it has beneficial effects on the altered metabolic processes and at the same time is capable of strengthening the immune system. The theory, which reveals the anticancer capacity of estrogen, may cut a small pathway in the jungle of cancer research. Hopefully, within a few years it will be widened to a highway on which many clinicians and researchers will rush to reach higher levels in prevention and cure of cancer.
This book containing the author's results on oral cancer raises a new concept concerning tumor initiation. Not estrogen, but its deficiency may provoke malignant transformation. This new theory may explain many controversial literary data concerning the associations of female sexual steroids and maliginancies.
Contents
Chapter 1 Global Trends in Oral Cancer Epidemiology in the XXth Century
Index
Nowadays, all anticancer agents have severe, toxic effects, killing the hemopoetic cells and thoroughly suppressing the immune system of the patient. One of our old dreams may come true with recognition of the anticancer capacity of estrogen. This new panacea is ideal for cancer cure as it has regulatory effects on cell proliferation and opposes growth factor activities. Moreover, it has beneficial effects on the altered metabolic processes and at the same time is capable of strengthening the immune system. The theory, which reveals the anticancer capacity of estrogen, may cut a small pathway in the jungle of cancer research. Hopefully, within a few years it will be widened to a highway on which many clinicians and researchers will rush to reach higher levels in prevention and cure of cancer.
This book containing the author's results on oral cancer raises a new concept concerning tumor initiation. Not estrogen, but its deficiency may provoke malignant transformation. This new theory may explain many controversial literary data concerning the associations of female sexual steroids and maliginancies.
Contents
Chapter 1 Global Trends in Oral Cancer Epidemiology in the XXth Century
- Traditional Risk Factors for Oral Cancer
- Controversial Changes in Oral Cancer Epidemiology
- Oral Cancer: Morbus Hungaricus in the XXIst Century
- Epidemiological Changes of Oral Cancer Incidence over a 20-Year
- Calendar Period in Hungary
- Evaluation of the Epidemiological Changes in Oral Cancer Incidence in Hungary
- Necessity to Search for Further Cancer Risk Factors
- Correlation of Metabolic Syndrome (Insulin Resistance Syndrome) with Cancer Risk
- Hyperinsulinemia and Cancer Risk
- Insulin-Like Growth Factors and Cancer Risk
- Hyperglycemia and Cancer Risk
- Visceral Obesity and Cancer Risk
- Dyslipidemia and Cancer Risk
- Hypertension, Insulin Resistance and Cancer Risk
- Dietary Habits, Insulin Resistance and Cancer Risk
- Physical Activity, Insulin Resistance and Cancer Risk
- Darkness, Melatonin, Insulin Resistance and Cancer Risk
- Tobacco Use, Insulin Resistance and Cancer Risk
- Alcohol Consumption, Insulin Resistance and Cancer Risk
- Aging, Insulin Resistance and Cancer Risk
- Importance of Associations between Insulin Resistance and Cancer Risk
- Hyperglycemia and cancer risk
- Expression of Glucose Transporters (GLUTs) and Oral Cancer Risk
- Non-enzymatic Glycation of Different Structures in type-2 Diabetes and Oral Cancer Risk
- Overexpression of Matrix Metalloproteinases and Oral Cancer Risk
- Altered Inflammatory Reactions in Type-2 Diabetes and Oral Cancer Risk
- Altered Immunologic Reactions in type-2 Diabetes
- Type-2 Diabetes and Risk for Oral Precancerous Lesions
- Type-2 Diabetes and Cancer Risk
- Epidemiological Associations of Diabetes Mellitus and Risk for Oral Cancer in Hungary
- Correlations between Diabetes and Risk of Oral Premalignant and Malignant Lesions
- Correlations of Type-2 Diabetes and Progression of Oral Cancer
- Type-2 Diabetes and Prognosis of Oral Cancer
- Biological Effects of Sexual Steroids
- Advantageous Biological Effects of Estrogen
- Cardiovascular Complications in Premenopausal Women with Type-2
- Diabetes and in Postmenopausal Cases
- Androgens, Cardiovascular Diseases and Cancer Risk
- Female Longevity and its Sources
- Hormonal Influences on Longevity and Cancer Risk
- Literary Data Supporting the Carcinogenic Capacity of Estrogen
- Assumed Carcinogenic Capacity of Estrogen Based on Animal Experiments
- Epidemiological Data Suggesting Carcinogenic Capacity of Estrogen in Humans
- Assumptions for the Mechanism of Estrogen Carcinogenicity
- Controversial Associations of Hormone Replacement Therapy and Cancer Risk
- Revision of Results Concerning Carcinogenic Capacity of Estrogen
- Physiologically Elevated Level of Female Sexual Steroids in Humans
- Gender Related Risk Factors for Oral Cancer: Estrogen Deficiency and Elevated Fasting Glucose (Hungarian Case-Control Study)
- Systemic Risk Factors for Oral Cancer
- Estrogen Deficiency as Cancer Risk
- Molecular Mechanisms of Estrogen Action
- Estrogen Receptors and Their Actions
- Actions of Estrogen and ERs on Nonclassical Target Tissues
- Cross Talk between Receptor Signals of Estrogen and Growth Factors
- Estrogen Receptors and Human Cancers
- Risk Factors for Highly Hormone Related Cancers
- Shortcomings of Studies on Correlations of HRT Use and Cancer Risk
- Selection of Patients for HRT Studies
- Dynamics of Cancer Growth and Length of the Observational Period
- Awareness of Estrogen Receptor Positivity of Cancers
- Anticancer Capacity of HRT Use in Several Organs
- Estrogen Deficiency and Cancer Risk in Postmenopausal Women
- Moderate Estrogen Deficiency and Cancer Risk in Premenopausal Women
- Bewildering Differences between Cancer Epidemiology of Highly and Moderately Estrogen Sensitive Organs
- Extraovarian Estrogen Synthesis
- Risk of Antiestrogen Therapy for Postmenopausal Women with ER-positive Breast Cancer
- Estrogen Deficiency in Men
- Clinical Associations between Estrogen Deficiency and Insulin Resistance
- Molecular Mechanism of Estrogen Effect on Glucose Metabolism
- Effects of Estrogen on Lipid Metabolism
- Effects of Insulin on Steroid Hormone Production and on their Signals at Receptor Level
- Increased Cancer Risk of Insulin Resistance among Women as Compared with Men
- Increased Cancer Risk of Insulin Resistance among Postmenopausal as Compared with Premenopausal Cases
- Importance of Combined Insulin Resistance and Estrogen Deficiency as Cancer Risk
- Case-control Study of Non-smoker, Non-drinker Women with Oral Cancer in Hungary
- Risk Factors for Oral Cancer other than Tobacco and Alcohol
- Questions to be Answered in Oral Cancer Epidemiology
- Metabolic and Hormonal Associations of Hypothyroidism
- Similar Mechanisms of Genomic and Nongenomic Actions of Thyroid and Steroid Hormones
Index
Product Details
- Hardcover: 180 pages
- Publisher: Nova Science Pub Inc; 1 edition (October 2008)
- Language: English
- ISBN-10: 1604569492
- ISBN-13: 978-1604569490
- Product Dimensions: 10.2 x 7.2 x 0.7 inches